Obtaining Early Insights Into Safety and Efficacy: The Benefits of Preclinical In Vivo Imaging

The benefits of preclinical in vivo imagingFirst established as a standard practice in clinics, in vivo imaging also benefits translational or preclinical research. For the past 25 years, many studies have relied on in vivo imaging as a method to quantify treatment response and gain early insights on efficacy. Now, as the technology advances, researchers can expect to benefit from greater spatial resolution and software advancements that allow faster, cost-effective translation of study results.

“Imaging often gives you unique information that can’t be obtained any other way.  The phenomena that you would observe preclinically may be the same disease state in the clinical trial,” says Michael Cockman, Senior Scientist and Manager of the Imaging Center at Covance. “It’s common to hear from a client who wants to test a type of imaging, called a modality, in a particular disease state to find out if it is appropriate for clinical development later.” Continue reading

Unlocking Brain Tumor Biology: Covance’s Genomics Laboratory and the Institute for Systems Biology Begin to Unravel the Genetic Mechanisms of Gliobastoma Multiforme

Genomics DNA HelixIn March 2011, Covance’s Seattle-based Genomics Laboratory (CGL) collaborated with the Institute for Systems Biology (ISB), also based in Seattle, to collectively unravel the complex regulation of gene expression in Glioblastoma Multiforme (GBM), one of the most common and aggressive forms of brain cancer. By applying Covance’s expertise in genomics and next-generation sequencing (NGS) with ISB’s expertise in complex genomics networks, the researchers’ goal is to gain a greater understanding of GBM. Since joining forces, CGL and ISB have made significant headway towards elucidating the genetic mechanisms behind GBM.

Although considerable efforts have been applied to unravel the complicated genetic background of GBM – the most common and malignant of all gliomas − it still has an average survival time of a little more than one year after diagnosis. Currently, the best available therapy for treating GBM consists of surgery, radiation, and chemotherapy. However, the survival time for those inflicted with GBM remains low due to its highly invasive and infiltrative nature, which makes complete eradication of the tumor via surgical resection challenging.

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